发明名称 |
Cancer antigen-specific T-cell receptor gene, peptide encoded by the gene, and use of them |
摘要 |
Disclosed are: a nucleotide sequence and an amino acid sequence for CDR3 region of T-cell receptor (TCR) gene of WT1-specific cytotoxic T-cell (CTL) for WT1 protein; a method for the detection or treatment of cancer using the nucleotide sequence or the amino acid sequence; and a chip, a primer set, a kit, an apparatus and the like for use in the detection of cancer, each of which comprises the nucleotide sequence or the amino acid sequence. |
申请公布号 |
US9315865(B2) |
申请公布日期 |
2016.04.19 |
申请号 |
US200812529701 |
申请日期 |
2008.02.28 |
申请人 |
International Institute of Cancer Immunology, Inc. |
发明人 |
Sugiyama Haruo |
分类号 |
C07H21/04;C12Q1/68;C07K14/725;G01N33/574;G01N33/569 |
主分类号 |
C07H21/04 |
代理机构 |
Finnegan, Henderson, Farabow, Garrett & Dunner, LLP |
代理人 |
Finnegan, Henderson, Farabow, Garrett & Dunner, LLP |
主权项 |
1. A synthesized cDNA, comprising:
(1) a nucleotide sequence encoding the entire amino acid sequence of a complementarity determining region 3 (CDR3) of a vβ chain of a T-cell receptor (TCR) of a WT1-specific HLA-A*2402-positive cytotoxic T-cell (CTL), wherein the nucleotide sequence is selected from the group consisting of SEQ ID NOs: 1-200, or (2) the nucleotide sequence that is complementary to the full length of the nucleotide sequence of (1), wherein the cDNA further comprises a label attached to the cDNA, said label selected from fluorescent labels, radioactive labels, enzyme labels, and chromophore labels. |
地址 |
Osaka JP |