| 发明名称 | Subgroup B recombinant human adenovirus vector, and methods for constructing and for using the same | ||
| 摘要 | A method for constructing a subgroup B recombinant human adenovirus vector Ad11-5EP. The method includes substituting a 365 bp fragment including an enhancer and a promoter of an upstream coding sequence of Ad5 E1A for a corresponding region of a serotype Ad11 of the subgroup B human adenovirus vector by homologous recombination to construct the subgroup B recombinant human adenovirus vector Ad11-5EP. A subgroup B recombinant human adenovirus vector Ad11-5EP constructed by the method and the use thereof for treatment of tumors are also provided. | ||
| 申请公布号 | US9315827(B2) | 申请公布日期 | 2016.04.19 |
| 申请号 | US201314093078 | 申请日期 | 2013.11.29 |
| 申请人 | Beijing Bio-Targeting Therapeutics Technology Inc. | 发明人 | Wang Yaohe;Jiang Guozhong;Wong Hanshi;Cao Fengyu;Lemoine Nick |
| 分类号 | C12N15/64;C12N15/66;C12N15/86;A61K35/761 | 主分类号 | C12N15/64 |
| 代理机构 | Matthias Scholl, PC | 代理人 | Matthias Scholl, PC ;Scholl Matthias |
| 主权项 | 1. A method for constructing a subgroup B recombinant human adenovirus vector Ad11-5EP (SEQ ID NO: 1), the method comprising substituting a 365 by fragment comprising an enhancer and a promoter of an upstream coding sequence of Ad5 E1A (SEQ ID NO: 2) for a corresponding region of a serotype Ad11 (SEQ ID NO: 3) of the subgroup B human adenovirus vector by homologous recombination to construct the subgroup B recombinant human adenovirus vector Ad11-5EP (SEQ ID NO: 1). | ||
| 地址 | Beijing CN | ||