Antigen binding proteins that bind CCR2

摘要

There is disclosed compositions and methods relating to or derived from anti-CCR2 antibodies. More specifically, there is disclosed fully human antibodies that bind CCR2, CCR2-binding fragments and derivatives of such antibodies, and CCR2-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having CCR2 related disorders or conditions.

主权项

1. A recombinant fully human antibody of an IgG class that binds to a CC-Chemokine Receptor 2 (CCR2) epitope, wherein the antibody has a heavy chain variable domain sequence that is at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID NO. 1, SEQ ID NO. 25, and SEQ ID NO. 27, and has a light chain variable domain sequence that is at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID NO. 2, SEQ ID NO. 26, and SEQ ID NO. 28, and wherein the antibody has a heavy chain/light chain variable domain sequence pairing that is at least 95% identical to the amino acid sequences selected from the group consisting of SEQ ID NO. 1/SEQ ID NO. 2 SEQ ID NO. 25/SEQ ID NO. 26, and SEQ ID NO. 27/SEQ ID NO. 28.