| 发明名称 | Recombinant cytotoxin as well as a method of producing it | ||
| 摘要 | The subject of the present invention is a method of modifying proteinaceous toxins through the addition of an NLS motif. The resulting cytotoxin facilitates the selective elimination of proliferating cells, particularly tumor cells. | ||
| 申请公布号 | US9315552(B2) | 申请公布日期 | 2016.04.19 |
| 申请号 | US201113976914 | 申请日期 | 2011.12.29 |
| 申请人 | BIOINFOBANK SP. Z O. O. | 发明人 | Bujko Anna;Lukasiak Magdalena;Dastych Jaroslaw;Skupinska Miroslawa;Rodakowska Ewelina;Rychlewski Leszek |
| 分类号 | C07K14/21;C12N15/62;A61K38/00 | 主分类号 | C07K14/21 |
| 代理机构 | Law Office of Salvatore Arrigo and Scott Lee, LLP | 代理人 | Law Office of Salvatore Arrigo and Scott Lee, LLP |
| 主权项 | 1. A method of producing a recombinant cytotoxic exotoxin, the method comprising adding a human nuclear localization signal (NLS) motif amino acid sequence to the amino-acid sequence of a starting protein cytotoxic exotoxin to provide a recombinant cytotoxic exotoxin comprising an amino acid sequence consisting of the amino acid sequence of the starting protein cytotoxic exotoxin and the added NLS, wherein the resulting recombinant cytotoxic exotoxin has a decreased overall cytotoxicity in comparison to the cytotoxicity of the starting protein cytotoxic exotoxin. | ||
| 地址 | Poznan PL | ||