ENHANCED ANABOLIC CYTOKINE PRODUCTION AND DELIVERY SYSTEM

摘要

Techniques and devices for removing (filtering out) unwanted/inhibitory components (for example, products, byproducts and/or cell output such as inhibitory catabolic proteins) from a composition (for example, autologous fluid or serum) containing such unwanted/inhibitory components. The devices include at least one construct designed to contain a composition (for example, autologous fluid or serum) containing inhibitory/unwanted components (products, byproducts and/or output of cells such as inhibitory catabolic proteins). The construct is provided with interior walls including specific protein capturing means designed to remove the inhibitory/unwanted component(s) (for example, specific protein(s)) from the composition. Proteins targeted for capture include, but are not limited to, catabolic cytokines such as IL-1β, IL-α, IL-6, TNFα, IFNγ and MMPS as these proteins inhibit the healing process.

主权项

1. A method for selectively removing unwanted components from serum or autologous fluid, comprising:
incubating the serum or autologous fluid in a syringe having an internal syringe wall coated with a protein binding site, or passing the serum or autologous fluid through the syringe with the internal syringe wall coated with the protein binding site, the protein binding site configured to bind a catabolic cytokine; and removing the serum or autologous fluid from the syringe after the incubating step.