PHARMACEUTICAL COMPOSITION COMPRISING N1-CYCLIC AMINE-N5-SUBSTITUTED BIGUANIDE DERIVATIVES AS AN INGREDIENT FOR PREVENTING OR TREATING FIBROSIS

摘要

The present invention provides a novel use of N1-cyclic amine-N5-substituted biguanide derivatives for preparing a medicine for preventing or treating fibrosis. The N1-cyclic amine-N5-substituted biguanide derivatives according to the present invention are capable of effectively inhibiting fibrosis by effectively suppressing the EMT.

主权项

1. A method of preventing or treating fibrosis comprising administering a therapeutically effective amount of a N1-cyclic amine-N5-substituted biguanide derivative compound of Formula 1 below or a pharmaceutically acceptable salt thereof to a subject in need thereof: wherein R1 and R2 are taken together with nitrogen to which they are attached to form 4- to 7-membered C3-6 heterocycloalkyl or C3-6 heterocycloalkene; R3 is H; C3-7 cycloalkyl; C3-12 aryl; or C1-6 alkyl unsubstituted or substituted with C3-12 aryl or C3-12 heteroaryl; wherein C3-6 heterocycloalkyl, cycloalkyl, C3-12 aryl, or C3-12 heteroaryl is unsubstituted or substituted with at least one non-hydrogen substituent selected from the group consisting of halogen, C1-4 alkyl, and C1-4 alkoxy, and the non-hydrogen substituent is unsubstituted or further substituted with halogen.