HIF-2α INHIBITORS FOR TREATING IRON OVERLOAD DISORDERS
摘要
The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating iron overload disorders. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and reduced liver iron accumulation and serum iron parameters in both prophylactic and treatment mouse models.
申请公布号
WO2016057242(A1)
申请公布日期
2016.04.14
申请号
WO2015US52279
申请日期
2015.09.25
申请人
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人
BRUICK, RICHARD, KEITH;CHEN, YAOMIN;RUIZ, JULIO, CESAR, FRANCISCO