发明名称 SPIRO-INDOLINES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION (RSV)
摘要 Benzimidazoles of formula (I): wherein: one of X and Y is an N atom or a substituted C atom, and the other is CH; L is a single bond, C1-3 alkylene, C2-3 alkenylene or C2-3 alkynylene; R1 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 3- to 10-membered cycloalkyl, 5- to 10-membered heterocyclyl or 5- to 12- membered heteroaryl, each of which is unsubstituted or substituted; Z is halo, C1-6 haloalkyl, nitro, -CN, -N(R2)2, -OR2, -SR2, -S(=0)R2, or -S(=0)2R2; each R2 is independently hydrogen, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; and m is 0 or 1; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.
申请公布号 WO2016055780(A1) 申请公布日期 2016.04.14
申请号 WO2015GB52920 申请日期 2015.10.06
申请人 RE:VIRAL LTD 发明人 COCKERILL, STUART;MATHEWS, NEIL;WARD, SIMON;LUNN, GRAHAM;PARADOWSKI, MICHAEL;GASCON SIMORTE, JOSE MIGUEL
分类号 C07D401/06;A61K31/437;A61P31/14;C07D471/10 主分类号 C07D401/06
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