DRUG ENTRAPMENT EFFICIENCY AND SUSTAINED DRUG RELEASE OF CHLORAMPHENICOL LOADED POLYMERIC-IRON NANOPARTICLES

摘要

This invention harvests nanocomposite which enable targeted delivery of antibiotics. Biodegradable and biocompatible polymer such as diethylaminoethyl-cellulose (DEAE-Cellulose) are used in combination with iron, which contributes its magnetic characteristics to the nanocomposite. The nanoparticles produced could be used as carriers for releasing chloramphenicol at the targeted site for sustained release.

主权项

1. A method of preparing drug loaded polymeric iron nanoparticles comprising:
a) mixing and sonicating an equimolar solutions of diethylaminoethyl cellulose and sodium hydroxide; b) adding to solution (a), a clear equimolar solution of ferrous sulfate and sulfuric acid to form nanocomposite precipitates; c) centrifuging the nanocomposite precipitates and drying it; d) dispersing the dried nanocomposite precipitates in water and adding a solution of a drug to be loaded; and, e) centrifuging the mixture in step (d) and drying at above room temperature.