COMPOSITIONS AND KITS FOR ENZYMATIC DEBRIDEMENT AND METHODS OF USING THE SAME

摘要

A debridement enzyme for necrotic tissue is described that is not dependent upon proteolytic enzymatic activity but instead utilizes the amylase family of enzymes. The amylases (α-, β-, γ-amylase) are noted for the cleavage of the α-glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments. It has now been found that α-amylase is effective in the debridement of devitalized tissue.

主权项

1. A debridement composition comprising:
0.001 to 99.5 wt % of an amylase component, and at least one pharmaceutically or cosmetically acceptable carrier or excipient in an amount of up to 99.9 wt-%, wherein the percentages are based on a total weight of the debridement composition, wherein, if a proteolytic enzyme component is present, a ratio of the amylase component to the proteolytic enzyme component is at least 4:1.