TREATMENT OF TAUOPATHIES BY PASSIVE IMMUNIZATION TARGETING THE N-TERMINAL PROJECTION DOMAIN OF TAU

摘要

A method of treating tau pathologies, such as Alzheimer's disease, involving the administration of antibodies specific to the amino terminal region of human tau (amino acid residues 6-18 or 184-195) to provide passive immunization. The administration of such antibodies can reduce total tau levels, decrease tau hyperphosphorylation, and improve reference memory. Passive immunization with antibodies targeting the N-terminal projection domain of tau reduces both total and hyperphosphorylated tau was found effective in aged 3×Tg-AD mice, a generally accepted mouse model of Alzheimer's disease and frontotemporal dementia in humans.

主权项

1. A pharmaceutical composition for treating a subject having a tauopathy, comprising a non-naturally occurring antibody that binds to a portion of the N-terminal projection domain of tau.