PEPTIDE FOR INHIBITION OF BINDING BETWEEN ANGIOPOIETIN-2 AND INTEGRIN AND USE THEREOF

摘要

Angiopoietin-2 (Ang2) derived peptides, polypeptides, and peptide complexes, and a method for inhibition of binding between Ang2 and integrin and prevention and/or treatment of a disease caused by the activation of Ang2 or the binding between Ang2 and integrin using the peptide, polypeptides, and peptide complexes.

主权项

1. A method of inhibition of binding between angiopoietin-2 (Ang2) and integrin in a patient, the method comprising administering at least one peptide selected from the group consisting of:
a peptide comprising 5 to 25 consecutive amino acids of SEQ ID NO: 43 including the amino acids from the 11th to 15th positions of SEQ ID NO: 43, a peptide comprising 11 to 20 consecutive amino acids of SEQ ID NO: 44 including amino acids from the 6th to 15th positions of SEQ ID NO: 44, a peptide comprising the amino acid sequence of SEQ ID NO: 24, and a peptide comprising the amino acid sequence of SEQ ID NO: 40.