| 摘要 |
PROBLEM TO BE SOLVED: To provide novel engineered multilayered vascular tubes which are useful for therapeutic, diagnostic and research use, a method for producing the tubes, and uses for the tubes.SOLUTION: There is provided engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells. The multilayered vascular tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the engineered multilayered vascular tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold.SELECTED DRAWING: Figure 2 |
