发明名称 |
CODON OPTIMIZED IL-15 AND IL-15R-ALPHA GENES FOR EXPRESSION IN MAMMALIAN CELLS |
摘要 |
The present invention provides for nucleic acids improved for the expression of interleukin-15 (IL-15) in mammalian cells. The invention further provides for methods of expressing IL-15 in mammalian cells by transfecting the cell with a nucleic acid sequence encoding an improved IL-15 sequence.;The present invention further provides expression vectors, and IL-15 and IL-15 receptor alpha combinations (nucleic acid and protein) that increase IL-15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of IL-15 after DNA, RNA or protein administration in a subject (e.g. a mammal, a human). |
申请公布号 |
US2016102128(A1) |
申请公布日期 |
2016.04.14 |
申请号 |
US201514739796 |
申请日期 |
2015.06.15 |
申请人 |
The U.S.A as Represented by the Secretary of the Department of Health and Human Services |
发明人 |
Felber Barbara K.;Pavlakis George N. |
分类号 |
C07K14/54;C07K14/715 |
主分类号 |
C07K14/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Rockville MD US |