BIOMOLECULE ISOLATION AND THERMAL PROCESSING

摘要

Methods, devices and systems for hand-tag sample liquids, encapsulating liquids and magnetic particles are disclosed.

主权项

1. A method for handling a sample liquid containing magnetic particles and an encapsulating liquid, the sample liquid and encapsulating liquid being immiscible, the method comprising:
flowing the encapsulating liquid in a conduit; flowing the sample liquid in the conduit so that the sample liquid is (a) surrounded by the encapsulating liquid and (b) located at a predetermined trapping site within the conduit; immobilizing the magnetic particles at the trapping site by applying a magnetic field at the trapping site; heating the conduit at the trapping site, thereby heating the immobilized magnetic particles; and flowing an elution liquid in the conduit so that (a) the elution liquid is surrounded by the encapsulating liquid, (b) the sample liquid is flowed away from the trapping site, and (c) the elution liquid is flowed to the trapping site and surrounds the immobilized magnetic particles.