| 发明名称 |
CROSSLINKED ANTI-HIV-1 COMPOSITIONS FOR POTENT AND BROAD NEUTRALIZATION |
| 摘要 |
An anti-HIV-1 spike composition includes a first anti-HIV-1 antibody Fab and a second anti-HIV-1 antibody Fab linked by a DNA or protein linker molecule to form a crosslinked homo-diFab or hetero-diFab having improved viral potency and neutralization. The anti-HIV-1 antibody Fabs include anti-gp120 CD4, anti-gp120 V1V2, anti-gp120 V3, and anti-gp41. |
| 申请公布号 |
US2016102137(A1) |
申请公布日期 |
2016.04.14 |
| 申请号 |
US201514872051 |
申请日期 |
2015.09.30 |
| 申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
Bjorkman Pamela J.;Galimidi Rachel P.;West Anthony P.;Nussenzweig Michel C. |
| 分类号 |
C07K16/10;C12N15/113;C07K16/46 |
主分类号 |
C07K16/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising:
a first anti-HIV-1 antibody Fab; a second anti-HIV-1 antibody Fab; and a linker molecule conjugated between the C-terminus of the first anti-HIV-1 antibody Fab and the C-terminus of the second anti-HIV-1 antibody Fab. |
| 地址 |
Pasadena CA US |
