SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE USING LACTATE AS AN INDICATOR

摘要

The version provides in vadous embodinents. systemsa devices and methods relating to exv o organ care. In certain ernbodments, the irventon relates to maintains an organ ex-vvaat naraphsiologia conditions. The present application d ehbes a method for using iatate measurementit he arterial and the venous blood ines of an organ car System heart perfusion device to evaluate 1) the overaHl perfusion status of an isolated heart 2) the metabolic status of an isolated heart and 3) the overall vascular paency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cats unique ability to prod uce/generate lactate when they are starved of oxygen and to metabolize/utilize lactate for energy production when they are veel perfused with oxygen, NtD "N C'4--- ------- e 4' N' c: N --- - - " -- - ------------- Nx ---------