主权项 |
1. A method of predicting cancer emergence in a subject in need thereof, said method comprising
(a) obtaining from the subject at least one of (b) obtaining
(i) a molecular-scale measurement from the sample,(ii) a cellular scale measurement from the sample(iii) an organ-scale measurement from the subject, and(iv) an organism-scale measurement from the subject; (c) providing the measurements obtained from step (b) to a computer comprising a computer executable code for running a state-evolution simulation model of cancer emergence, wherein the measurements are used by the computer executable code as an initial parameter of the state-evolution simulation model, wherein the state-evolution model comprises
(i) a molecular-scale simulation model of the cancer,(ii) a cellular-scale simulation model of the cancer,(iii) a tissue-scale simulation model of the cancer,iv) an organism-scale simulation model of the cancer, and(v) instructions for refining the molecular-scale simulation model, cellular-scale simulation model, tissue-scale simulation model, and the organism-scale simulation model based upon output from the molecular-scale simulation model, cellular-scale simulation model, tissue-scale simulation model, and organism-scale simulation model; (d) using the computer, running the state-evolution simulation model to produce an output comprising a prediction of cancer state at the molecular-scale, cellular-scale, tissue-scale and organism-scale level; (e) comparing the output of the model to outputs obtained for results of at least one of each of (i) molecular-scale measurement, (ii) cellular-scale measurement, (iii) organ-scale measurement, and (iv) organism-scale measurement from a second subject of known progression status; (f) based upon the state-evolution simulation model output of (d) and the comparison of (e), generating a prediction of progression of the cancer in the subject; (g) selecting a treatment regimen to ameliorate symptoms associated with the prediction of progression of the cancer in the subject at risk of cancer progression; and (h) administering the treatment to the subject. |