发明名称 PSMA-BINDING AGENTS AND USES THEREOF
摘要 PROBLEM TO BE SOLVED: To provide compounds which allow easy incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET), and methods for imaging prostate cancer cells and angiogenesis that impart good contrast.SOLUTION: A compound includes as an imaging tracer a radioisotope substituent of the formula in the figure. (Y is NR' where R' is H or an alkyl group; Z is a carboxyl group, ester group or tetrazole group; Q is H or a protective group; and R is an alkanoyl group having as a substituent a specific group having a radioisotope substituent of F, I or the like.)SELECTED DRAWING: None
申请公布号 JP2016053025(A) 申请公布日期 2016.04.14
申请号 JP20150174731 申请日期 2015.09.04
申请人 UNIV JOHNS HOPKINS 发明人 MARTIN GILBERT POMPER;RONNIE CHARLES MEASE;CHEN YING
分类号 C07C275/16;A61K31/197;A61K31/225;A61K31/32;A61K31/44;A61K51/00;A61P35/00;C07D213/56;C07F7/22 主分类号 C07C275/16
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