发明名称 |
Protection Against Ionizing Radiation and Chemotherapy Toxicity via Latexin Regulation |
摘要 |
The present invention relates to methods for protecting against damage caused by radiation and/or chemotherapy, and methods for treating bone marrow damage by reducing/inhibiting Latexin expression and/or Latexin activity. The methods comprise administering to a subject in need thereof a pharmaceutical composition comprising an antagonist that reduces expression and/or activity of latexin, wherein latexin is a latexin polynucleotide variant and/or a latexin polypeptide variant that binds to the antagonist. |
申请公布号 |
US2016102311(A1) |
申请公布日期 |
2016.04.14 |
申请号 |
US201514879577 |
申请日期 |
2015.10.09 |
申请人 |
University of Kentucky Research Foundation |
发明人 |
VAN ZANT Gary;Liang Ying;Liu Yi |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
1. A method for protecting against the hematopoietic stem cell (HSC) damage caused by chemotherapy and/or radiation, the method comprising:
administering to a subject in need thereof a pharmaceutical composition comprising an antagonist that reduces expression and/or activity of latexin, wherein latexin is a latexin polynucleotide variant and/or a latexin polypeptide variant that binds to the antagonist. |
地址 |
Lexington KY US |