摘要 |
The invention relates to a process for preparing glycopyrronium bromide in the form of [R,S] and [S.R] diastereoisomers, the method consisting in separation of these desired diastereoisomers from the mixture of [R,S3, [S,R], [R,R] and [S,S] diastereoisomers by means of two or more controlled crystallizations from a solution of a solvent selected from the group consisting of 1-propanol, 2-propanol, 1-butanol, and tert-butanol. |
申请人 |
ZENTIVA, K.S. |
发明人 |
OBADALOVA, IVA;CHVOJKA, TOMAS;HRUBY, JAN;DAMMER, ONDREJ;TKADLECOVA, MARCELA;REITMAJER, JOSEF;NOVOTNA, NADEZDA;LEHNERT, PETR |