| 摘要 |
PROBLEM TO BE SOLVED: To provide a composition including LINGO antibody or fragment thereof.SOLUTION: Endogenous LINGO-I is a negative regulator against neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous LINGO-I function, such as anti-LINGO-1 antibodies, can be used as a treating agent for neuron and oligodendrocyte dysfunction. The invention provides antibodies specific for LINGO-I and methods for using such antibodies as an antagonist of endogenous LINGO-I function. The invention further provides monoclonal antibodies derived from a specified hybridoma and phage library, nucleic acids encoding these antibodies and vectors and host cells containing these antibodies.SELECTED DRAWING: Figure 9 |
