| 摘要 |
The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (TGFpRI), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, preferably colon cancer, melanoma, hepatocellular carcinoma, renal cancer, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung cancer, and gastric cancer, and/or fibrosis, preferably liver fibrosis and chronic kidney disease. |
| 申请人 |
ELI LILLY AND COMPANY |
发明人 |
BEIGHT, DOUGLAS W.;COATES, DAVID A.;JOSEPH, SAJAN;MCMILLEN, WILLIAM T.;PARTHASARATHY, SARAVANAN;PEI, HUAXING;SAWYER, JASON SCOTT;WOLFANGEL, CRAIG D.;ZHAO, GAIYING |
