发明名称 |
NANO-LIPOSOMAL AMINOGLYCOSIDE-THYMOQUINONE FORMULATIONS |
摘要 |
The nano-liposomal aminoglycoside-thymoquinone formulations are suitable for administration to a mammal and include an aminoglycoside antibiotic (amikacin, gentamicin, or tobramycin) and thymoquinone (TQ) encapsulated within a liposome. The liposome-encapsulated aminoglycoside-thymoquinone (TQ) formulations can be administered to a subject in need thereof. The liposome-encapsulated aminoglycoside-thymoquinone formulations are prepared by a method, which comprises forming a lipid film from a mixture of phospholipids and cholesterol; mixing the lipid film with methanol containing thymoquinone in molar ratio; evaporating off the methanol from the mixture; adding polysaccharides and/or polyethylene glycol (PEG) in PBS (phosphate-buffered saline) buffer in volume ratio to form a liposomal mixture; sonicating the liposomal mixture for at least five minutes; adding an aminoglycoside antibiotic in molar ratio with the thymoquinone; sonicating the mixture for at least five minutes; lyophilizing the liposomal aminoglycoside-thymoquinone formulation; and storing it at −80° C. until use. |
申请公布号 |
US2016101124(A1) |
申请公布日期 |
2016.04.14 |
申请号 |
US201414513114 |
申请日期 |
2014.10.13 |
申请人 |
KING ABDULLAH INTERNATIONAL MEDICAL RESEARCH CENTER ;KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES ;NATIONAL GUARD HEALTH AFFAIRS |
发明人 |
HALWANI MAJED ABDULAZIZ;BALKHY HANAN HASSAN |
分类号 |
A61K31/7036;A61K45/06;A61K9/127;A61K31/122 |
主分类号 |
A61K31/7036 |
代理机构 |
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代理人 |
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主权项 |
1. A composition, comprising an aminoglycoside antibiotic and thymoquinone encapsulated within a common liposome. |
地址 |
RIYADH SA |