发明名称 |
COMPOSITION FOR HEAT MELT EXTRUSION AND METHOD FOR PRODUCING HEAT MELT EXTRUDED PRODUCT USING SAME |
摘要 |
Provided is a composition for hot melt extrusion comprising a drug and hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more and a mole ratio of an acetyl group to a succinyl group of less than 1.6. Further, provided is a method for producing a hot melt extrudate comprising the step of hot melt-extruding a composition for hot melt extrusion comprising a drug and hypromellose acetate succinate having a molar hydroxypropoxy substitution of 0.40 or more and a mole ratio of an acetyl group to a succinyl group of less than 1.6, at a hot melt temperature of not lower than a melting temperature of the hypromellose acetate succinate or of not lower than a temperature at which both the hypromellose acetate succinate and the drug are melted. |
申请公布号 |
EP3006049(A1) |
申请公布日期 |
2016.04.13 |
申请号 |
EP20140806945 |
申请日期 |
2014.06.03 |
申请人 |
SHIN-ETSU CHEMICAL CO., LTD. |
发明人 |
WARASHINA, SHOGO;KUSAKI, FUMIE;KIKUCHI, KAZUKI;OBARA, SAKAE;MARUYAMA, NAOSUKE |
分类号 |
A61K47/38;A61K9/20;C08B11/08 |
主分类号 |
A61K47/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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