发明名称 |
USE OF A TRUNCATED CCN1 PROMOTER FOR CANCER DIAGNOSTICS, THERAPEUTICS AND THERANOSTICS |
摘要 |
Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by a truncated CCN 1 cancer selective promoter (tCCN1-Prom) are provided, as are cells and transgenic animals that contain such vectors. The vectors are used in cancer therapy and/or diagnostics, and the transgenic mice are used to monitor cancer progression, e.g. in screening assays. |
申请公布号 |
EP3003022(A1) |
申请公布日期 |
2016.04.13 |
申请号 |
EP20140817622 |
申请日期 |
2014.06.04 |
申请人 |
VIRGINIA COMMONWEALTH UNIVERSITY |
发明人 |
FISHER, PAUL, B.;DAS, SWADESH, K.;DASH, RUPESH;SARKAR, DEVANAND;SARKAR, SIDDIK;WINDLE, JOLENE |
分类号 |
A01K67/027;A61K48/00;C12N15/86 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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地址 |
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