发明名称 |
A BIOMIMETIC PEPTIDE AND BIODEGRADABLE DELIVERY PLATFORM FOR THE TREATMENT OF ANGIOGENESIS- AND LYMPHANGIOGENESIS-DEPENDENT DISEASES |
摘要 |
Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, an isolated peptide comprising the amino acid sequence LRRFSTAPFAFIDINDVINF, which exhibits anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models is disclosed. The isolate peptide also exhibits anti-lymphangiogenic and directly anti-tumorigenic properties. |
申请公布号 |
EP3003343(A1) |
申请公布日期 |
2016.04.13 |
申请号 |
EP20140807179 |
申请日期 |
2014.06.09 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
POPEL, ALEKSANDER, S.;PANDEY, NIRANJAN, B.;LEE, ESAK;GREEN, JORDAN, J.;SHMUELI, RON, B. |
分类号 |
A61K38/00;A61K38/10;C12N5/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|