发明名称 |
ACELLULAR PRO-TOLEROGENIC COMPOSITIONS FOR TREATMENT/PREVENTION OF GRAFT REJECTION |
摘要 |
This invention relates to cellular-based therapies for increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. To provide these therapeutic effects, two allogeneic leukocyte populations are contacted (in vivo, in vitro or ex vivo) and one of these leukocyte population is modified to bear on its surface a low-immunogenic biocompatible polymer so as to prevent pro-inflammatory allo-recognition. Cellular-based preparations and processes for achieving cellular therapy are also provided. |
申请公布号 |
EP2872152(A4) |
申请公布日期 |
2016.04.13 |
申请号 |
EP20130817327 |
申请日期 |
2013.07.12 |
申请人 |
CANADIAN BLOOD SERVICES |
发明人 |
SCOTT, MARK D.;WANG, DUNCHENG;TOYOFUKU, WENDY M. |
分类号 |
A61K35/14;A61K31/7105;A61K47/30;A61P37/02;C12N5/078;C12N5/0783 |
主分类号 |
A61K35/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|