发明名称 |
METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS |
摘要 |
The present disclosure provides methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, including rheumatoid arthritis, having the structure of Formula (I): wherein R1, R2, R3, R4, R5 and X are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound. |
申请公布号 |
EP3003039(A1) |
申请公布日期 |
2016.04.13 |
申请号 |
EP20140808115 |
申请日期 |
2014.06.06 |
申请人 |
CONFLUENCE LIFE SCIENCES, INC.;HOCKERMAN, SUSAN, L.;MONAHAN, JOSEPH B.;SELNESS, SHAUN, R. |
发明人 |
HOCKERMAN, SUSAN, L.;MONAHAN, JOSEPH, B.;SELNESS, SHAUN, R. |
分类号 |
C07D401/14;A61K31/444;A61K31/506;A61K45/06;C07D213/69 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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