发明名称 |
METHOD FOR SYNTHESIZING OPTICALLY ACTIVE -AMINO ACID USING CHIRAL METAL COMPLEX COMPRISING AXIALLY CHIRAL N-(2-ACYLARYL)-2-[5,7-DIHYDRO-6H-DIBENZO[c,e]AZEPIN-6-YL]ACETAMIDE COMPOUND AND AMINO ACID |
摘要 |
Objects of the present invention are to provide an industrially applicable method for producing an optically active ±-amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active ±,±-disubstituted ±-amino acid, and to provide an intermediate useful for the above production methods of an optically active ±-amino acid and an optically active ±,±-disubstituted ±-amino acid. The present invention provides a production method of an optically active ±-amino acid or a salt thereof, the production method comprising introducing a substituent into the ± carbon in the ±-amino acid moiety of a metal complex represented by the following Formula (1):
by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure ±-amino acid enantiomer or a salt thereof by acid decomposition of the metal complex. |
申请公布号 |
EP3006449(A1) |
申请公布日期 |
2016.04.13 |
申请号 |
EP20140801345 |
申请日期 |
2014.03.27 |
申请人 |
HAMARI CHEMICALS, LTD. |
发明人 |
MORIWAKI, HIROKI;KAWASHIMA, AKI;TAKEDA, RYOSUKE;KAWAMURA, AKIE;SOLOSHONOK VADIM A. |
分类号 |
C07F15/04;C07B53/00;C07C227/32;C07C229/24;C07C229/30;C07C229/36;C07C229/48;C07C231/18;C07C237/06;C07C319/20;C07C323/58;C07D213/55;C07D223/14 |
主分类号 |
C07F15/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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