| 摘要 |
in one aspect., the present Invention provides a method of determining cardiovascular disease (CVD) risk in a subject comprising (a) determining fatty acid composition of lipids In a sample obtained from the subject, wherein the lipids are selected from the group consisting of: (I) triacylgiycerols (TAGs); and cholesterol esters (CEs); and (b) comparing the fatty acid composition of the lipids in the sample from the subject to a control; wherein a decrease in mean fatty acid chain length in the lipids in the sample from the subject compared to the control indicates an. increased risk of CVD in the subject; and wherein the. CVD is associated with atherosclerotic plaque rupture or thrombosis., and/or the CVD Is an acute ischemic event selected from myocardial infarction, ischemic stroke or sudden cardiac death. |
