发明名称 |
BILE ACIDS FOR INDUCING HEPATIC DIFFERENTIATION |
摘要 |
The present invention pertains to a method for promoting the differentiation of mesenchymal stem cells into mature hepatocytes or hepatocyte progenitors. To this end the invention employs bile acid receptor agonists, in particular bile acids such as tauroursodeoxycholic acid (TUDCA), for inducing the hepatic differentiation process in a mesenchymal stem cell population. Hepatocytes or their progenitors as produced in accordance with the methods of the invention will find application for liver regeneration, in organ or cell transplantation, and as a treatment of degenerative liver diseases such as liver cancer or liver cirrhosis. |
申请公布号 |
EP3006557(A1) |
申请公布日期 |
2016.04.13 |
申请号 |
EP20140188006 |
申请日期 |
2014.10.07 |
申请人 |
HEINRICH HEINE UNIVERSITÄT DÜSSELDORF |
发明人 |
HÄUSSINGER, DIETER;KORDES, CLAUS;SAWITZA, IRIS |
分类号 |
C12N5/071;A61K31/575 |
主分类号 |
C12N5/071 |
代理机构 |
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代理人 |
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地址 |
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