发明名称 |
IDENTIFYING DESIRABLE T LYMPHOCYTES BY CHANGE IN MASS RESPONSES |
摘要 |
In certain embodiments methods of identifying T cell receptors that respond to specific target cell antigens are provided, where the methods comprise providing a substrate bearing a plurality of target cells (e.g., mammalian cells); contacting the target cells on the substrate with CD8+ T cells; and using label-free optical imaging to identify an increase in mass of a T-cell and/or a decrease in mass of a target cell, where an increase in mass of a T cell and/or a decrease in mass of a target cell is an indicator that said T cell bears a T cell receptor activated by antigens presented on said target cell. |
申请公布号 |
EP3004373(A1) |
申请公布日期 |
2016.04.13 |
申请号 |
EP20140801181 |
申请日期 |
2014.05.23 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
TEITELL, MICHAEL A.;ZANGLE, THOMAS A.;WITTE, OWEN N.;LINTON, DAINA BURNES |
分类号 |
C12Q1/02;G01N33/48 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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