<i>Salmonella enterica </i>presenting <i>C. jejuni </i>N-glycan or derivatives thereof

摘要

The present invention relates to Salmonella enterica comprising at least one pgl operon of Campylobacter jejuni or a functional derivative thereof and presenting at least one N-glycan of Campylobacter jejuni or N-glycan derivative thereof on its cell surface. In addition, it is directed to medical uses and pharmaceutical compositions thereof as well as methods for treating and/or preventing Campylobacter and optionally Salmonella infections and methods for producing these Salmonella strains.

主权项

1. Salmonella enterica, comprising at least one pgl operon of Campylobacter jejuni and further comprising at least one N-glycan of Campylobacter jejuni on its cell surface, wherein one or more genes for bacillosamine biosynthesis are inactivated by mutation or partial or complete deletion.