2-substituted imidazo[4,5-D]phenanthroline derivatives and their use in the treatment of cancer

摘要

The present invention provides 2-substituted imidazo[4,5-d]phenanthroline compounds, which are capable of inhibiting proliferation of one or more renal cancer cells, pancreatic cancer cells, prostate cancer cells, colon cancer cells, leukemia cells, brain cancer/tumor cells or non-small cell lung cancer cells.

主权项

1. A compound of formula (I): or a salt or solvate thereof, wherein:
between C and X, and between C and Y designates a single or a double bond, and at least one of is a single bond;X is optionally substituted alkoxy or NR3R4 when between C and X is single bond, orX is O when between C and X is a double bond;Y is N when between C and Y is a double bond, or Y is NH, when between C and Y is a single bond;R1 and R2 are independently H, optionally substituted alkyl, or optionally substituted alkoxy, andR3 and R4 are taken together to form a 5 or 6 membered optionally substituted heterocycle, having at least one heteroatom that is N or O; andprovided that when X is O and between C and X is a double bond; then R1 and R2 both are not H.