Ophthalmic contact lens solutions containing forms of vitamin B

摘要

The present invention relates to improved ophthalmic solutions that employ select B vitamins; pyridoxine and its salts; and thiamine and its salts in order to more effectively preserve solutions and to reduce the degree to which cationic preservatives will deposit on contact lenses. Ophthalmic solutions are here understood to include contact lens treatment solutions, such as cleaners, soaking solutions, conditioning solutions and lens storage solutions, as well as wetting solutions and in-eye solutions for treatment of eye conditions.

主权项

1. A contact lens solution comprising:
at least 0.00001 weight percent of a cationic preservative selected from the group consisting of polyhexamethylene biguanide and polyquaternium-1; 0.00001 to 10 weight percent of a preservative enhancer chosen from the group consisting of: pantothenic acid (B5); a salt of pantothenic acid; panthenol; a salt of panthenol; dexpanthenol; a salt of dexpanthenol; and combinations thereof, wherein the contact lens solution has a low chloride concentration of less than 0.2 mole percent chloride, and the combination of cationic preservative, preservative enhancer, and the low chloride concentration provide an enhanced preservative effect relative to a corresponding contact lens solution having a chloride concentration of more than 0.2 mole percent.