| 主权项 |
1. A process for preparing an epoxide-containing azaepothilone of formula VIIwherein RA is selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl,
RB is selected from the group consisting of H, alkyl, and substituted or unsubstituted aryl, RC is selected from the group consisting of H, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and fluoroalkyl, the process comprising:
a) contacting a bornane derivative of a compound of formula II wherein Z is selected from the group consisting of, andR1 and R2 are independently selected from the group consisting of hydrogen, triethylsilyl (TES), triisopropylsilyl (TIPS), tent-butyldimethylsilyl (TBS) and tert-butyldiphenylsilyl (TBDPS),with a vinyl halide of formula III wherein X is a halide, and R3 and R4 are independently selected from the group consisting of H, tert-butyloxycarbonyl (BOC), and tert-butylsulfonyl (SO2t-Bu), or together R3 and R4 are CPh2,in the presence of a transition metal catalyst to provide a compound of the formula IV andb) converting the compound of formula IV to a compound of formula V by converting Z to OH and converting R3 and R4 to H when one or both of R3 and R4 are other than H, wherein the converting steps are conducted in any order; andc) cyclizing the compound of formula V to the compound of formula VI d) treating a compound of formula VI with an epoxidizing agent to form a compound of formula VIII ande) deprotecting the compound of formula VIII to provide the epoxide containing azaepothilone VII. |
