Substituted 6-fluoro-1H-pyrazolo[4,3-b]pyridines and use thereof

摘要

The present application relates to novel substituted 6-fluoro-1H-pyrazolo[4,3-b]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for preparing Medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.

主权项

1. A compound of formula (I) in which R1 represents hydrogen or (C1-C4)-alkyl,
where (C1-C4)-alkyl may be substituted by one or two substituents independently of one another selected from the group consisting of fluorine and trifluoromethyl, R2 represents (C1-C4)-alkyl, (C3-C7)-cycloalkyl or a 4- to 7-membered heterocycle,
where (C1-C4)-alkyl may be substituted by one or two substituents independently selected from the group consisting of fluorine, trifluoromethyl and (C3-C7)-cycloalkyl, R3 is (C1-C6)-alkyl or benzyl,
where (C1-C6)-alkyl is substituted by one trifluoromethyl substituent,where (C1-C6)-alkyl may be substituted by 1 to 3 fluorine substituents, andwhere benzyl is substituted by 1 to 3 fluorine substituents, or a salt thereof.