STABILITY-MODULATING LINKER USED WITH ANTIBODY DRUG CONJUGATE

摘要

PROBLEM TO BE SOLVED: To provide an antibody drug conjugate (ADC) in which stable characteristics are modified by the portion for modulation on a linker of ADC.SOLUTION: The invention provides an ADC using a linker represented by formula (I). [M is a stability modulation group; P is a peptide sequence comprising one or more glutamine residues; Q is a glutamine residue in P; E is each independently -C(R1)2-, -O-C(R1)2-C(R1)2- (if r is 2 or more) or -C(R1)2-C(R1)2-O- (if s is 1 or more); R1 is H, an alkyl of straight/branched chain of C1-6, an alkenyl of straight/branched chain of C2-6, or an alkynyl of straight/branched chain of C2-C6; X and Y are amino acids; Z is a spacer element; m is 0-5; n is 1-5; p is 0-2; q is 0-10; r is 0-2; s is 0-2; q+r+s≥2; and D is a cytotoxic agent.]SELECTED DRAWING: None