| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to field of organic chemistry, namely to alkaloid derivatives, based on aminoesters of general formulaand to their pharmaceutically acceptable salts, wherein Rrepresents phenyl, optionally substituted with one-three substituents, selected from the group, consisting of halogen atoms, COOH; Rrepresents phenyl, optionally substituted with one substituent, selected from the group, consisting of halogen atoms; W is selected from the group, consisting of phenyl, naphthalenyl and heteroaryl (selected from dihydrobenzodioxynyl, dihydrobenzodioxepinyl, dihydrobenzoxazinyl and thiophenyl), with each of phenyl and naphthalenyl is optionally substituted with one or two substituents, similar or different, selected from the group, consisting of halogen atoms, -NO, -CN, (C-C)alkyl, (C-C)alkoxy, halogen(C-C)alkyl, halogen(C-C)alkoxy, heterocyclyl (selected from pyrrolidinyl, morpholinyl), phenyl, phenyloxy, halogenphenyl, (C-C)alkyl-NHCO -(C-C)alkyl, -OR, -N(R), -SR, -OSOR, -COR, -OCOR, -CON(R), -NHCOR, -NHCOR, -NHSOR, -NHCO-(C-C)alkyl-COOH, -CO-(C-C)alkyl-N (R)and -CO-morpholinyl; Rrepresents H or is selected from the group, consisting of (C-C)alkyl; Arepresents physiologically acceptable anion, selected from Cl, Br, TFA. The invention also relates to application of formula (I) compound.EFFECT: novel heterocyclic compounds, useful as antagonists of muscarine receptors, have been obtained.10 cl, 12 tbl, 39 ex |
