| 摘要 |
FIELD: biotechnology; biochemistry.SUBSTANCE: invention relates to a known compounds representing derivatives (8-(trifluoromethyl)benzo[f][1,2,3,4,5]pentathiepin-6-yl)amides of general formula I, having ability to inhibit human enzyme tyrosyl-DNA-phosphodiesterase 1.EFFECT: increased inhibitory action on enzyme of human tyrosyl-DNA-phosphodiesterase 1 (Tdp1) and wider range of inhibitors of this enzyme.1 cl, 2 dwg, 1 tbl, 8 ex |
