| 摘要 |
The present invention relates to methods for the diagnosis of subjects that have or are at risk of having Alzheimer's disease (AD). In particular the present invention identifies individuals who have or are at risk of having AD through measurement of the levels of Afamin in combination with at least one other biomarker such as Alpha-1-antichymotrypsin, Alpha-2-macroglobulin, ApoB100, Complement C5, Serine threonine protein kinase TBK1 or Complement C3 in a fluid sample taken from a subject. Furthermore, genotype (Apolipoprotein E or glutathione S-transferase Omega) may also be taken into consideration and used within classification algorithms to determine the probability of a subject having or being at risk of having AD. |
| 主权项 |
1. A method of diagnosing or monitoring a person at risk of developing or having Alzheimer's disease (AD) comprising obtaining a fluid sample from a person suspected of having or at risk of developing AD, measuring the concentration or relative level of the biomarker Afamin and at least one additional biomarker selected from Alpha-1 antichymotrypsin, Alpha-2-macroglobulin, Apolipoprotein B100, complement C3, Serine threonine kinase TBK-1, vitamin D binding protein, alpha-1-B glycoprotein, hemopexin, serum albumin, ceruloplasmin, alpha-2-antiplasmin, apolipoprotein A1, complement factor H, IgG, IgG Fc binding protein, hornerin, fibrinogen, complement C5 in the fluid sample, and establishing the significance of the concentrations or relative levels. |
