HUMAN MONOCLONAL ANTIBODIES SPECIFIC FOR 5T4 AND METHODS OF THEIR USE

摘要

Fully human monoclonal antibodies that bind 5T4 are described. 5T4 is a tumor- associated antigen expressed in a variety of carcinoma tumors, including in colorectal, ovarian, renal, non-small cell lung and gastric tumors, but with limited expression in normal adult tissues. Antibody-drug conjugates (ADCs), chimeric antigen receptors (CARs), immunoconjugates and compositions that include the fully human 5T4-specific monoclonal antibodies are also described. The disclosed antibodies and compositions can be used, for example, in the diagnosis and treatment of 5T4-positive cancers.