| 发明名称 |
SUBLINGUAL FENTANYL SPRAY |
| 摘要 |
The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable sale thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations. |
| 申请公布号 |
US2016095846(A1) |
申请公布日期 |
2016.04.07 |
| 申请号 |
US201514966301 |
申请日期 |
2015.12.11 |
| 申请人 |
Insys Pharma, Inc. |
发明人 |
Kottayil S. George;Goskonda Venkat R.;Zhu Zhongyuan;Kattookaran Linet;Parikh Neha |
| 分类号 |
A61K31/4468;A61K47/10;A61K9/00 |
主分类号 |
A61K31/4468 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A sublingual spray formulation for the treatment of pain comprising:
(i) from about 0.1% to about 0.8% by weight of fentanyl, a free base or a pharmaceutically acceptable salt thereof, or a derivative thereof; (ii) from about 50% to about 60% by weight of ethanol; and (iii) from about 4% to about 6% by weight of propylene glycol,wherein the formulation provides a mean Tmax of about 1.28+/−0.60, is propellant-free and comprises droplets having a mean diameter of at least about 10 microns. |
| 地址 |
Chandler AZ US |
