ENGINEERED LEATHER AND METHODS OF MANUFACTURE THEREOF

摘要

Engineered animal skin, hide, and leather comprising a plurality of layers of collagen formed by cultured animal collagen-producing (e.g., skin) cells. Layers may be formed by elongate multicellular bodies comprising a plurality of cultured animal cells that are adhered and/or cohered to one another; wherein the elongate multicellular bodies are arranged to form a substantially planar layer for use in formation of engineered animal skin, hide, and leather. Further described herein are methods of forming engineered animal skin, hide, and leather utilizing said layers of animal collagen-producing cells.

主权项

1. A method of producing an engineered leather, the method comprising:
culturing one or more types of collagen-producing cells in vitro; forming a plurality of sheets of extracellular matrix including collagen produced by the one or more types of collagen-producing cells; layering the plurality of sheets to form a body having a volume; allowing the layered sheets to fuse; and processing the body by tanning to modify the collagen.