发明名称 |
ANIMAL MODELS, CELL LINES AND METHODS FOR SCREENING HEPATITIS C VIRUS VACCINES |
摘要 |
Modified non-human mammalian hepatoma cell lines that express hepatitis C virus (HCV) antigens and which are capable of generating tumours in a syngeneic animal model are provided. The cell lines are generated by genomic integration of an expression construct that comprises one or more HCV antigen-encoding sequences under the control of a constitutive promoter. The expression construct further comprises a selectable marker and a reporter gene under the control of the same promoter. The cell lines are useful for testing prophylactic and therapeutic vaccines against HCV either in vitro or in vivo. |
申请公布号 |
WO2016049769(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
WO2015CA50989 |
申请日期 |
2015.10.01 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
YOUNG, KEVIN;KRISHNAN, LAKSHMI |
分类号 |
C12N15/85;A01K67/027;C12N5/10;C12N15/51;C12Q1/00;C12Q1/02;C12Q1/68;C12Q1/70 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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