CROSSLINKED ANTI-HIV-1 COMPOSITIONS FOR POTENT AND BROAD NEUTRALIZATION
摘要
An anti-HIV-1 spike composition includes a first anti-HIV-1 antibody Fab and a second anti-HIV-1 antibody Fab linked by a DNA or protein linker molecule to form a crosslinked homo-diFab or hetero-diFab having improved viral potency and neutralization. The anti-HIV-1 antibody Fabs include anti-gpl20 CD4, anti-gpl20 V1V2, anti-gpl20 V3, and anti-gp41.
申请公布号
WO2016054296(A2)
申请公布日期
2016.04.07
申请号
WO2015US53371
申请日期
2015.09.30
申请人
CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人
BJORKMAN, PAMELA, J.;GALIMIDI, RACHEL, P.;WEST, ANTHONY, P.;NUSSENZWEIG, MICHEL, C.
