PERIODONTAL TISSUE GRAFTS

摘要

The present invention relates to implantable decellularized biphasic periodontal tissue grafts, methods for their manufacture, and use of such grafts for the treatment of periodontal defects, periodontal diseases and periodontal tissue regeneration; said decellularized biphasic periodontal tissue graft comprises: a first polymeric scaffold comprising a plurality of first polymer fibers, and a second polymeric scaffold comprising a plurality of second polymer fibers; wherein said first and second polymeric scaffolds are interconnected; said first polymer fibers are arranged such that said first polymeric scaffold has a porous structure with an average first pore size, and said second polymer fibers are arranged such that said second polymeric scaffold has a porous structure with an average second pore size; said first polymer fibers are coated with an osteoblast-derived extracellular matrix, and said second polymer fibers are coated with a periodontal ligament cell-derived extracellular matrix.