发明名称 |
MARKERS OF POOR PROGNOSIS ACUTE MYELOID LEUKEMIAS (AMLS) AND USES THEREOF |
摘要 |
Genes exhibiting specific mutational and/or transcriptional patterns in poor prognosis AMLs, such as EVI1-rearranged acute myeloid leukemias (EVI1-r AMLs), relative to other types of AMLs and/or normal CD34+ cells, are disclosed. The use of these mutational and/or transcriptional patterns, for example the expression level of the PRKC Apoptosis WT1 Regulator (PAWR) gene, for the diagnosis or prognosis of AMLs, including intermediate-risk AMLs, is also disclosed. |
申请公布号 |
WO2016049752(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
WO2015CA50462 |
申请日期 |
2015.05.21 |
申请人 |
UNIVERSITÉ DE MONTRÉAL;RSEM, LIMITED PARTNERSHIP |
发明人 |
SAUVAGEAU, GUY;LAVALLÉE, VINCENT-PHILIPPE;HÉBERT, JOSÉE;LEMIEUX, SÉBASTIEN;LEHNERTZ, BERNHARD |
分类号 |
C12Q1/68;C07H21/04;C12N15/12;C40B30/04;G01N33/50 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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