PREDICTION OF RESPONSE TO PARP INHIBITORS AND COMBINATIONAL THERAPY TARGETING C-MET AND PARP1

摘要

Provided herein are methods for identifying and treating cancers that are resistant to PARP inhibition. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided. In some aspects, PARP inhibitor cancers are treated with a PARP inhibitor therapy in combination with a c-Met inhibitor therapy.